GenomeCraft offers an array of proprietary computational services for the maximization of the biosynthetic production of a desired compound. Theses services include:
- Host suitability selection
- Host pathway design, including assessment and minimization for the toxicity potential of the design
- Network optimization by identifying and reducing flux through competing pathways
- Identification of key genes within a pathway that are non-redundant and minimize toxicity effects of internal metabolites (optimal MAGE targets)
Besides computational approaches GenomeCraft partners with third parties to provide mutant library-based experimental approaches to:
- Experimentally select for gene knockouts that show target metabolite buildup
- Enhance genetic stability of designed strains